1.
Acta Diabetol
; 58(5): 669-670, 2021 05.
Article
in English
| MEDLINE | ID: covidwho-1061121
2.
Diabetes Res Clin Pract
; 164: 108220, 2020 Jun.
Article
in English
| MEDLINE | ID: covidwho-306383
3.
Diabetes Res Clin Pract
; 163: 108162, 2020 May.
Article
in English
| MEDLINE | ID: covidwho-127824
ABSTRACT
Diabetes could be a risk factor for severity and mortality in patients with coronavirus disease 2019 COVID-19. It has been hypothesized that DPP4 inhibition, a therapy currently available for type 2 diabetes, might represent a target for decreasing the risk of the acute respiratory complications of the COVID-19 infection but (1) lack of demonstration of SARS-CoV2 binding to DPP4 (2) possible protective role of sDPP4 in Middle East respiratory Syndrome (MERS-CoV) (3) demonstrated inhibition and downregulation of DPP4 by HIV1 and MERS-CoV and (4) not exclusive role of the receptor binding in tropism of the Coronavirus family, support that DPP4 inhibition at present doesn't represent a plausible approach to mitigate COVID-19.